CAY10416 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Dual cyclooxygenase-
2 (COX-
2)/5-
lipoxygenase (5-
LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-
2/5-
LO inhibitor with IC
50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-
fold for COX-
2
versus COX-
1. COX-
2/5-
LO inhibitors such as CAY10416 are also apoptosis-
inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 μM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC
50 value of 83 μM.
CAY10416 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
