8-BROMO-2-CHLOROQUINAZOLINE
- CAS No.
- 956100-63-3
- Chemical Name:
- 8-BROMO-2-CHLOROQUINAZOLINE
- Synonyms
- 2-chloro-8-bromoquinazoline;8-BROMO-2-CHLOROQUINAZOLINE;8-BroMo-2-chloroquinazoli...;Quinazoline, 8-bromo-2-chloro-;8-Bromo-2-chloroquinazoline 97%
- CBNumber:
- CB01517840
- Molecular Formula:
- C8H4BrClN2
- Molecular Weight:
- 243.49
- MDL Number:
- MFCD11043845
- MOL File:
- 956100-63-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Risk Statements | 41 |
| Safety Statements | 26-39 |
| RIDADR | UN2811 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
8-BROMO-2-CHLOROQUINAZOLINE price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B684733 | 8-Bromo-2-chloroquinazoline | 956100-63-3 | 250mg | $55 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB42522 | 8-Bromo-2-chloroquinazoline | 956100-63-3 | 1g | $425 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 38143 | 8-Bromo-2-chloroquinazoline 95+% | 956100-63-3 | 1g | $495 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H32-D-88 | 8-Bromo-2-chloroquinazoline | 956100-63-3 | 1g | $608 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB42522 | 8-Bromo-2-chloroquinazoline | 956100-63-3 | 2g | $680 | 2021-12-16 | Buy |
8-BROMO-2-CHLOROQUINAZOLINE Chemical Properties,Uses,Production
Synthesis
956100-62-2
956100-63-3
General procedure for the synthesis of 8-bromo-2-chloroquinazoline from 4-amino-8-bromo-2-chloroquinazoline: 8-bromo-2-chloroquinazolin-4-amine (12.93 g, 50 mmol) was dissolved in THF (500 mL) under stirring conditions, and isoamyl nitrite (23.43 g, 200 mmol) was added slowly dropwise over a dropwise period of 3 hours. Subsequently, the reaction mixture was continued to be stirred at 60 °C for 40 min. Upon completion of the reaction, the progress of the reaction was monitored by TLC (unfolding agent: PE:EA = 1:1). When the reaction was complete, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The residue was dissolved in DCM (300 mL) and the organic layer was washed sequentially with brine (100 mL) and water (100 mL). The organic layer was dried over anhydrous Na2SO4 and purified by column chromatography (eluent: DCM:PE = 1:1) to afford the target compound 8-bromo-2-chloroquinazoline as a yellow solid (8.21 g, 67% yield).1H NMR (DMSO-d6, 400 MHz): δ 9.66 (s, 1H), 8.45 (dd, J = 0.8, 7.6 Hz, 1H), 8.26 (dd, J = 0.8, 8.0 Hz, 1H), 7.73 (dd, J = 7.6, 8.0 Hz, 1H).
References
[1] Patent: WO2007/125405, 2007, A2. Location in patent: Page/Page column 25; 81-82
[2] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0191; 0195
[3] Patent: WO2015/27222, 2015, A2. Location in patent: Paragraph 0216
[4] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0484-0485
8-BROMO-2-CHLOROQUINAZOLINE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
