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ChemicalBook >> CAS DataBase List >>(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE

(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE

CAS No.
111821-58-0
Chemical Name:
(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE
Synonyms
(S)-(-)-HA-966;(S) ( ) HA 966,(S)()HA 966;S(-)-HA-966 S(-)-3-AMINO-1-HYDROX;(S)-3-Amino-1-hydroxy-2-pyrrolidinone;(3S)-3-Amino-1-hydroxy-2-pyrrolidinone;(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE;2-Pyrrolidinone, 3-amino-1-hydroxy-, (3S)-;(S)-(-)-3-Amino-1-hydroxypyrrolidine-2-one
CBNumber:
CB1775697
Molecular Formula:
C4H8N2O2
Molecular Weight:
116.12
MDL Number:
MFCD00078584
MOL File:
111821-58-0.mol
Last updated:2025-04-17 18:22:24

(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Properties

Melting point 166℃
Boiling point 259℃
Density 1.436
Flash point 110℃
storage temp. Store at RT
pka 7.19±0.20(Predicted)
form Powder
color Off-white to light yellow
Water Solubility Soluble to 100 mM in water
FDA UNII 3C1G86U80C

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 0282 (S)-(-)-HA-966 ≥98%(HPLC) 111821-58-0 50 $269 2021-12-16 Buy
Tocris 0282 (S)-(-)-HA-966 ≥98%(HPLC) 111821-58-0 10 $63 2021-12-16 Buy
TRC H105815 (S)-(-)-HA-966 111821-58-0 2.5mg $160 2021-12-16 Buy
ApexBio Technology B6244 (S)-(-)-HA-966 111821-58-0 10mg $156 2021-12-16 Buy
ApexBio Technology B6244 (S)-(-)-HA-966 111821-58-0 50mg $669 2021-12-16 Buy
Product number Packaging Price Buy
0282 50 $269 Buy
0282 10 $63 Buy
H105815 2.5mg $160 Buy
B6244 10mg $156 Buy
B6244 50mg $669 Buy

(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Chemical Properties,Uses,Production

Uses

(S)-(-)-HA-966 is an NMDA antagonist/partial agonist and is a potent sedative with ataxic action.

Biological Activity

Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms.

in vivo

(S)-(-)-HA 966 ((-)-HA 966; 3 and 5 mg/kg; i.p.) prevents restraint stress-induced dopamine utilization in both the medial prefrontal cortex and nucleus accumbens. (S)-(-)-HA 966 suppresses fear-induced behaviors: immobility and defecation[1].
(S)-(-)-HA 966 (3 mg/kg; i.p.) prevents locomotor sensitization without altering the acute motoric response elicited by cocaine[1].
(S)-(-)-HA 966 (5 mg/kg; i.p.) blocks acute cocaine-induced locomotion but resulted in sedation[1].

IC 50

NMDA Receptor

111772-93-1
111821-58-0
Synthesis of (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE from Carbamic acid, (1-hydroxy-2-oxo-3-pyrrolidinyl)-, phenylmethyl ester, (S)- (9CI)

(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Preparation Products And Raw materials

(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49730 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19939 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 info@dycnchem.com China 53900 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5691 66
Atop-Pharma (Shanghai) Technology Co., Ltd. +86 (21) 5196-9732 China 996 57
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Zhengzhou Huiju Chemical Co., Ltd. 0371-55900031 18137872243 2853979815@qq.com China 9993 55

View Lastest Price from (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(-)-HA 966 pictures 2024-10-28 (S)-(-)-HA 966
111821-58-0
 US $837.00 / mg 10g TargetMol Chemicals Inc.
(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE (S)-(-)-HA-966 S(-)-HA-966 S(-)-3-AMINO-1-HYDROX (S)-(-)-3-Amino-1-hydroxypyrrolidine-2-one (3S)-3-Amino-1-hydroxy-2-pyrrolidinone (S)-3-Amino-1-hydroxy-2-pyrrolidinone 2-Pyrrolidinone, 3-amino-1-hydroxy-, (3S)- (S) ( ) HA 966,(S)()HA 966 111821-58-0 4H8N2O2 Glutamate receptor