3-Chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-1H-pyrrole-2,5-dione
![3-Chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-1H-pyrrole-2,5-dione Structure](CAS/20210305/GIF/2762315-39-7.gif)
- CAS No.
- 2762315-39-7
- Chemical Name:
- 3-Chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-1H-pyrrole-2,5-dione
- Synonyms
- 3-Chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-1H-pyrrole-2,5-dione
- CBNumber:
- CB213461607
- Molecular Formula:
- C18H11ClF4N4O3
- Molecular Weight:
- 442.75
- MDL Number:
- MOL File:
- 2762315-39-7.mol
3-Chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-1H-pyrrole-2,5-dione Chemical Properties,Uses,Production
Uses
TRPC5-IN-4 is potent and safe TRPC inhibitor with IC50 value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD)[1].
IC 50
TRPC5: 14.07 nM (IC50); TRPC4: 65 nM (IC50)
References
[1] Zhang Z, Chen L, Tian H, et al. Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors. Bioorg Med Chem Lett. 2022;61:128612. DOI:10.1016/j.bmcl.2022.128612
3-Chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-1H-pyrrole-2,5-dione Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-1H-pyrrole-2,5-dione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20701 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |