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FebuxostatDescyano???

FebuxostatDescyano??? ??? ???

?? ??:: 1206550-99-3

???:: FebuxostatDescyano???

???(??):: FebuxostatDescyano???

???:: Febuxostat Descyano Impurity

???(??):: Febuxostat-5;3-Descyano Febuxostat;Febuxostat Impurity IV;Febuxostat Descyano Impurity;2-(4-isobutoxyphenyl)-4-methylthiazole;2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid;2-[4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic Acid;5-Thiazolecarboxylic acid, 4-methyl-2-[4-(2-methylpropoxy)phenyl]-;Febuxostat Impurity 13/Febuxostat Descyano Impurity/2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid

CBNumber:: CB13118914

???:: C15H17NO3S

??? ??:: 291.37

MOL ??:: 1206550-99-3.mol

?? ?? 63

FebuxostatDescyano??? ??

???: 192-194°C

?? ?: 471.5±55.0 °C(Predicted)

??: 1.213±0.06 g/cm3(Predicted)

?? ??: Hygroscopic, -20°C Freezer, Under inert atmosphere

???: DMSO(?? ???), ???(?? ???)

?? ?? (pKa): 1.30±0.37(Predicted)

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FebuxostatDescyano??? C??? ??, ??, ??

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3-Descyano Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

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FebuxostatDescyano??? ?? ??

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FebuxostatDescyano??? ?? ??:

Febuxostat 2-(3-cyano-4-isopropoxyphenyl)-4-methylthiazole-5-carboxylic acid 2-(4-HYDROXY-PHENYL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ethyl 2-(4-butoxy-3-formylphenyl)-4-methylthiazole-5- carboxylate FeBuxostat Impurity 32 2-(4-(sec-butoxy)-3-cyanophenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Bromo Impurity Febuxostat Impurity 14 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid 2,2'-[4-(2-Methylpropoxy)-1,3-phenylene]bis[4-Methyl-5-thiazolecarboxylic Acid ethyl 2-(4-butoxy-3-cyanophenyl)-4-methylthiazole-5- carboxylate FeBuxostat Impurity 18 ethyl 2-(3-cyano-4-isopropoxyphenyl)-4-methylthiazole-5- carboxylate 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat impurity 37 FeBuxostat Impurity 33 FeBuxostat Impurity 26 Febuxostat Acyl-β-D-glucuronide

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