ChemicalBook >?? ???? >MPP+?????
MPP+?????
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MPP+????? ??
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- 166-168 °C
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- desiccated
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| ??? ?? | T | ||
|---|---|---|---|
| ?? ???? ?? | 23/24/25-36/37/38-25 | ||
| ????? | 26-36-45 | ||
| ????(UN No.) | UN 2811 6.1/PG 2 | ||
| WGK ?? | 3 | ||
| RTECS ?? | UU6580000 |
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MPP+ iodide is an active metabolite of the dopaminergic neurotoxin MPTP.?? ??
1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.Biochem/physiol Actions
MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.MPP+????? ?? ?? ? ???
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