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MMP-9/MMP-13???I

MMP-9/MMP-13???I
MMP-9/MMP-13???I ??? ???
?? ??:
204140-01-2
???:
MMP-9/MMP-13???I
???(??):
MMP-9/MMP-13???I
???:
MMP-9/MMP-13 INHIBITOR I
???(??):
MMP-9/MMP-13 INHIBITOR I;MMP-9/MMP-13 INHIBITOR II;N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYLPIPERAZINE-2-CARBOXAMIDE;N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-(4-BIPHENYLCARBONYL)PIPERAZINE-2-CARBOXAMIDE;2-Piperazinecarboxamide, 4-([1,1'-biphenyl]-4-ylcarbonyl)-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-
CBNumber:
CB7427176
???:
C25H25N3O6S
??? ??:
495.55
MOL ??:
Mol file
MSDS ??:
SDS

MMP-9/MMP-13???I ??

??
1.364±0.06 g/cm3(Predicted)
?? ??
-20°C
???
DMSO ?? ???? ???
?? ?? (pKa)
9.38±0.23(Predicted)
??? ??
??
??? ??
??? ??
??
White to off-white
??
Light Sensitive
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405 ???? ?????.
NFPA 704
0
2 0

MMP-9/MMP-13???I C??? ??, ??, ??

??

MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.

??

A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13

MMP-9/MMP-13???I ?? ?? ? ???

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MMP-9/MMP-13???I ?? ??

???( 21)?? ??
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Nextpeptide Inc
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Aladdin Scientific

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