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| 1-(BENZYLOXYCARBONYL) AZETIDINE-3-CARBOXYLIC ACID Basic information |
Product Name: | 1-(BENZYLOXYCARBONYL) AZETIDINE-3-CARBOXYLIC ACID | Synonyms: | 1-(BENZYLOXYCARBONYL) AZETIDINE-3-CARBOXYLIC ACID;1-Cbz-azetidine-3-carboxylic acid;N-Cbz-azetidine-3-carboxylic acid;1-benzyloxycarbonyl-3-azetidinecarboxylic acid;1-Cbz-azetidine-3-carboxy...;CBZ-AZETIDINE-3-CARBOXYLIC ACID;N-(Benzyloxycarbonyl)azetidine-3-carboxylic acid, 95%;Azetidine-1,3-dicarboxylic acid 1-benzyl ester | CAS: | 97628-92-7 | MF: | C12H13NO4 | MW: | 235.24 | EINECS: | | Product Categories: | | Mol File: | 97628-92-7.mol |  |
| 1-(BENZYLOXYCARBONYL) AZETIDINE-3-CARBOXYLIC ACID Chemical Properties |
Boiling point | 421.2±45.0 °C(Predicted) | density | 1.362 | storage temp. | 2-8°C | pka | 4.19±0.20(Predicted) | form | Solid | color | White to off-white |
HazardClass | IRRITANT | HS Code | 2933998090 |
| 1-(BENZYLOXYCARBONYL) AZETIDINE-3-CARBOXYLIC ACID Usage And Synthesis |
Uses | 1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] | IC 50 | Non-cleavable Linker | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268 [2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| 1-(BENZYLOXYCARBONYL) AZETIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials |
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