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SYNTHESIS, CHARACTERIZATION AND ANTITUMOUR ACTIVITY OF 5-CHLOROURACIL AND 5-CHLOROURACIL-HISTIDINE COMPLEXES WITH SOME METAL(III) IONS

Published:1 January 1998 DOI: 10.1080/00945719809351652
K. Narang,?V. Singh,?D. Bhattacharya

Abstract

Abstract Complexes of the type [AIL(OH)CI], [ML(OH)2] and [M′LL′(H2O)CI], where HL = 5-chlorouracil; HL′ = histidine; M = Cr(III) or Fe(III) and M′ = Al(III), Cr(III) or Fe(III), were synthesized and characterized. The complexes are polymeric in nature showing high decomposition points and are insoiuble in water and common organic solvents. 5-Chlorouracil is coordinated to the metal ion through the O atom of C(4)[dbnd]O and the N atoni of N(1) while histidine through the O atom of -COO? and the N atom of -NH2 group. The μeff values, electronic spectral bands and ESR spectra suggest a polymeric 6-coordinate spin-free octahedral stereochemistry for the Cr(III) and Fe(III) complexes. In vivo and in vitro antitumour activity results indicate that the Cr(III) complexes have significant activity against P815 murine mastocytoma but the Al(III) complexes show poor activity.

Substances (5)

Related products
Procduct Name CAS Molecular Formula Supplier Price
5-Chlorouracil 1820-81-1 C4H3ClN2O2 469 suppliers $5.00-$1210.00
DL-Histidine 4998-57-6 C6H9N3O2 259 suppliers $9.90-$1363.65
IRON (III) ISOPROPOXIDE 14995-22-3 C9H21FeO3 30 suppliers $33.65-$1803.00
NH -MIL-53(Al) 1134360-62-5 C8H5AlNO5 17 suppliers Inquiry
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