2-Acetylamidomethyl-4-(4-fluorobenzyl)morpholine synthesis
- Product Name:2-Acetylamidomethyl-4-(4-fluorobenzyl)morpholine
- CAS Number:112913-94-7
- Molecular formula:C14H19FN2O2
- Molecular Weight:266.31
112913-95-8
20 suppliers
$155.00/100mg
352-11-4
382 suppliers
$5.00/25g
112913-94-7
82 suppliers
$8.00/10g
Yield:-
Reaction Conditions:
with potassium iodide;potassium carbonate in butanone;
Steps:
R.6 Preparation of 2-acetylaminomethyl-4-(4-fluorobenzyl)morpholine
REFERENCE EXAMPLE 6 Preparation of 2-acetylaminomethyl-4-(4-fluorobenzyl)morpholine A mixture of 2-acetylaminomethylmorpholine (7.0 g), 4-fluorobenzyl chloride (12 g), potassium carbonate (56 g), potassium iodide (1 g), and methyl ethyl ketone (100 ml) is refluxed with stirring for 17 hours. The reaction mixture is filtered and the filtrate is concentrated under reduced pressure. The residue is diluted with water and extracted with chloroform. The organic layer is separated, washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. The solvent is distilled off under reduced pressure, and the residue is recrystallized from toluene to give the title compound (9.3 g), mp 120°-122° C.
References:
US4870074,1989,A
![Acetamide, N-[[4-(phenylmethyl)-2-morpholinyl]methyl]-](/CAS/20210305/GIF/112913-96-9.gif)
112913-96-9
2 suppliers
inquiry
112913-94-7
82 suppliers
$8.00/10g
22116-33-2
101 suppliers
$35.00/200μmol
112913-94-7
82 suppliers
$8.00/10g
108-24-7
0 suppliers
$14.00/250ML
![4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine](/CAS/GIF/112914-13-3.gif)
112914-13-3
158 suppliers
$5.00/250mg
112913-94-7
82 suppliers
$8.00/10g