2-Amino-4-methoxy-6-methyl-1,3,5-triazine synthesis
- Product Name:2-Amino-4-methoxy-6-methyl-1,3,5-triazine
- CAS Number:1668-54-8
- Molecular formula:C5H8N4O
- Molecular Weight:140.14
24771-25-3
124-42-5
1668-54-8
Example 2: Acetamidine hydrochloride (9.5 g) was added to a solution of methanol (50 mL) and potassium hydroxide particles (6.8 g) pre-cooled to 10°C. Subsequently, dimethyl N-cyanoimido carbonate (11.4 g) was dissolved in 40 mL of methanol and this solution was slowly added dropwise to the above reaction mixture. After the dropwise addition was completed, the reaction mixture was stirred continuously at 25°C for 2 hours. Upon completion of the reaction, the mixture was poured into 40 mL of ice water to quench the reaction. The resulting solid crystals were collected by filtration and washed sequentially with water and methanol. Finally, the product was dried at 70 °C overnight to afford 11.8 g of 2-amino-4-methyl-6-methoxy-1,3,5-triazine in 84% yield.
Yield:1668-54-8 84%
Reaction Conditions:
with potassium hydroxide in methanol;(2S)-N-methyl-1-phenylpropan-2-amine hydrate
Steps:
2 EXAMPLE 2
EXAMPLE 2 Acetamidine hydrochloride (9.5 g) was added to a predissolved solution of methanol (50 mL) and KOH pellets (6.8 g) at 10° C. It was then dropped into a solution of 11.4 g of dimethyl N-cyanoimidocarbonate and 40 mL of methanol at 10° C. After the addition, the reaction mixture was stirred at 25° C. for 2 hours onto 40 mL of ice water. The solid crystals were collected by filtering and washing with water and methanol. After drying at 70° C. overnight, 11.8 g (84% yield) of 2-methyl-4-amino-6-methoxy-1,3,5-triazine was obtained.
References:
E. I. Du Pont de Nemours and Company US5070199, 1991, A
82097-50-5
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1668-54-8
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$8.00/10g