4-Amino-2-(trifluoromethyl)benzonitrile synthesis
- Product Name:4-Amino-2-(trifluoromethyl)benzonitrile
- CAS Number:654-70-6
- Molecular formula:C8H5F3N2
- Molecular Weight:186.13
876322-73-5
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Yield:654-70-6 98.9%
Reaction Conditions:
with ammonium bisulphate;acetic acid in toluene; for 16 h;Reflux;Solvent;
Steps:
1; 2; 3
Add the above 18.8kg of intermediate to a 500L reactor4-amino-2-trifluoromethylbenzaldehyde and 200 kg of toluene and 1.88 kg of acetic acid and11.45kg ammonia hydrogen sulfate, heated to reflux for 16h, added 200kg water and 3kg sodium hydroxide, Stir for 1h, stand for 1h, separate liquid, discard the water layer, keep the oil layer,Pull out 100kg of toluene under reduced pressure, reduce the temperature to -5 ~ 0 degrees, and filter to obtain 18.4kg4-amino-2-trifluoromethylbenzonitrile with a yield of 98.9% and a purity of 99.9%.
References:
CN110862334,2020,A Location in patent:Paragraph 0023-0028
320-47-8
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654-70-6
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