Minocycline hydrochloride synthesis
- Product Name:Minocycline hydrochloride
- CAS Number:13614-98-7
- Molecular formula:C23H28ClN3O7
- Molecular Weight:493.94
10118-90-8
176 suppliers
$15.00/100mg
13614-98-7
554 suppliers
$5.00/50mg
Yield:13614-98-7 92.7%
Reaction Conditions:
with hydrogenchloride in ethanol at 0 - 5; pH=1 - 2; for 1 h;Solvent;
Steps:
21-22
General procedure: 10g of Intermediate IV was dissolved in 30ml methanol, cooled to 0-5°C, concentrated hydrochloric acid was added dropwise to adjust Ph to 1-2, after stirring for 1h, a white suspension was obtained, filtered, the filter cake was washed with a small amount of methanol, and dried to obtain 9g of white solid powder (minocycline hydrochloride), the molar yield is 83.4%, and the HPLC purity is 98.5%.
References:
CN112574057,2021,A Location in patent:Paragraph 0024; 0052-0053
64-73-3
312 suppliers
$11.00/25mg
13614-98-7
554 suppliers
$5.00/50mg