苯唑青霉素鈉
| 中文名稱 | 苯唑青霉素鈉 |
|---|---|
| 中文同義詞 | 安迪靈;苯唑青;新青Ⅱ號;新青霉素;青霉素 P-12 鈉鹽;苯唑西林鈉;苯甲異噁唑青霉素鈉;新青霉素II |
| 英文名稱 | Oxacillin sodium monohydrate |
| 英文同義詞 | OXACILLIN NA;OXACILLIN SODIUM SALT HYDRATE VETRANAL,;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-diMethyl-6-[[(5-Methyl-3-phenyl-4-isoxazolyl)carbonyl]aMino]-7-oxo-,sodiuM salt, hydrate (1:1:1), (2S,5R,6R)-;Oxacillin sod;Oxacillin Sodium Salt (2S,5R,6R)-3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, sodium salt, hydrate (1:1:1);5-Methyl-3-phenyl-4-isoxazol penicillin sodium monohydrate;Oxacillin sodium monohydrate |
| CAS號 | 7240-38-2 |
| 分子式 | C19H20N3NaO6S |
| 分子量 | 441.43 |
| EINECS號 | 629-150-0 |
| 相關(guān)類別 | 青霉素類;小分子抑制劑，天然產(chǎn)物;其它試劑;抗生素及抗病毒;抗生素;醫(yī)藥原料;醫(yī)藥化工類;醫(yī)藥原料藥;原料藥;醫(yī)藥、農(nóng)藥及染料中間體;生化試劑;化學(xué)試劑;醫(yī)用原料;獸藥原料;Antibiotics for Research and Experimental Use;beta-Lactams (Antibiotics for Research and Experimental Use);Biochemistry;beta-Lactam StructureEPA;1694 Pharmaceuticals&Personal Care Products;Alphabetic;Antibiotics;BactericidalAntibiotics;Chemical Structure;NeatsAnalytical Standards;O;Principle;Stains and Dyes;Stains&Dyes, A to;通用生化試劑-抗生素;對照品;Peptide Synthesis/Antibiotics;Inhibitors |
| Mol文件 | 7240-38-2.mol |
| 結(jié)構(gòu)式 |  |
苯唑青霉素鈉 性質(zhì)
| 熔點 | 188 C |
|---|---|
| 沸點 | 687℃ |
| 比旋光度 | D20 +201° (c = 1 in water) |
| 折射率 | 205 ° (C=1, H2O) |
| 閃點 | >110°(230°F) |
| 儲存條件 | Inert atmosphere,2-8°C |
| 溶解度 | 易溶于水，溶于甲醇，幾乎不溶于二氯甲烷。 |
| 形態(tài) | 固體 |
| 顏色 | 白色到近乎白色 |
| PH值 | pH (30g/l, 25℃) : 4.5～7.5 |
| 水溶解性 | Freely soluble in water |
| Merck | 14,6904 |
| BRN | 4287093 |
| InChIKey | ZVIYWUUZWWBNMB-VICXVTCVSA-M |
| SMILES | C([C@H]1C(S[C@]2([H])[C@@H](C(N21)=O)NC(C1=C(ON=C1C1C=CC=CC=1)C)=O)(C)C)(=O)[O-].[Na+].O |
| CAS 數(shù)據(jù)庫 | 7240-38-2(CAS DataBase Reference) |
Oxacillin sodium monohydrate (Methicillin)是一種抗菌劑，是一種窄譜，青霉素類的β-內(nèi)酰胺類抗生素。
Oxacillin exhibits MIC values of ≤1 μg/mL for four
mecA
gene-carrying
S. aureus
clinical isolates (SA 1306, SA 1326, SA 1552, and SA 4666.
Oxacillin (5 μg/mL, 0-90 min) induces lysis of Tol
+
and Tol
-
strains.
Cell Viability Assay
| Cell Line: | Cells of S. aureus which had grown for six to eight generations in [ 14 C]glycerol. |
| Concentration: | 5 μg/mL. |
| Incubation Time: | 0, 30, 60, 90 min. |
| Result: | The Tol + isolates were readily distinguished from Tol- isolates by the rates at which the cells lysed. |
化學(xué)性質(zhì)
白色結(jié)晶性粉末。熔點188℃（分解），易溶于水、甲醇、二甲基亞砜，微溶于水乙醇、氯仿，極微溶于丙酮、丁醇，不溶于乙醚、苯。用途
半合成的耐酸耐酶青霉素。臨床主要用于耐藥金葡菌感染，如敗血癥、肺炎、化膿性腦膜炎和骨髓炎等。生產(chǎn)方法
6-氨基青霉烷酸與苯甲異噁唑酰氯縮合、成鹽而得。安全信息
| 危險品標志 | Xn,Xi |
|---|---|
| 危險類別碼 | 36/37/38-42/43 |
| 安全說明 | 22-26-36/37 |
| WGK Germany | 3 |
| 海關(guān)編碼 | 29411099 |
| 毒性 | LD50 orally in rats: >8000 mg/kg (Goldenthal) |